From the perspective of biology, the rules for the game of life are simple: acquire energy, avoid becoming food for someone else in the process, and pass on your genetic information. This simple theme has given rise to an incredibly rich and diverse panoply of approaches and solutions. Strange Survivors, written by Puerto Rican biologist Oné R. Pagán, is a love letter to the many wonders that biology has to offer. I am sure he would approve if I said: “Prepare to be amazed!”