programmed cell death (PCD)

Book review – The Evolutionary Origins of Life and Death

9-minute read
keywords: abiogenesis, cell biology, evolutionary biology

In this second foray into the biology of death, I will examine programmed cell death or PCD. You might have heard of the process of apoptosis, but, as the previously reviewed The Biology of Death mentioned, this is just one of many ways in which cells can actively kill themselves. It is a vital part of life in multicellular organisms, for instance sculpting our hands so that we are not born with webs of skin between our fingers, or allowing leaves to fall from the trees in autumn by triggering cell death in so-called abscission zones. These are small sacrifices to serve the larger organism. Surprisingly, single-celled (unicellular) organisms also show PCD. But wait, is that not tantamount to suicide? How did that evolve?

(more…)

Book review – The Biology of Death: How Dying Shapes Cells, Organisms, & Populations

7-minute read
keywords: biomedicine, molecular biology

Though humans have shrouded it in ritual, cultural, and religious meaning, death is fundamentally a biological phenomenon. As both a biologist and someone with an abiding interest in the gothic subculture, death has thus never been a topic I shy away from. Two recent books, The Biology of Death (2022), and The Evolutionary Origins of Life and Death (first published in 2020), provided the perfect excuse to indulge my morbid curiosity.

(more…)

Book review – The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer

7 -minute read

Fifty years ago, US President Richard Nixon declared a “war on cancer” when he signed the National Cancer Act. Despite fantastic progress on some fronts, overall it is clear that we are not winning this battle. Cancer remains one of the leading causes of human mortality. But what if the tired war-metaphor is getting it all wrong? Brimming with thought-provoking questions, The Cheating Cell looks at cancer through an evolutionary lens and forces the reader to radically reconsider cancer; not as a bug, but as a feature of life.

(more…)

Book review – The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance

After the recently published Lamarck’s Revenge: How Epigenetics Is Revolutionizing Our Understanding of Evolution’s Past and Present left me little the wiser on how epigenetics actually works, I decided to track down a copy of Nessa Carey’s The Epigenetics Revolution. As one of two popular books published around the same time, it seemed like a good place to start. Peter Ward was right about one thing, this is indeed a landmark book, even if it is now a few years old.

(more…)

Book review – The Enlightened Gene: Biology, Buddhism, and the Convergence That Explains the World

I sometimes wonder whether I am a closet Buddhist. Now, I will be the first to admit that I know next to nothing about Buddhism, but what little I have encountered often strikes a chord with me. The Enlightened Gene shows there might be a good reason for this. This book chronicles a most unlikely project: the Emory-Tibet Science Initiative. On the invitation of the Dalai Lama no less (!), Emory University has developed a science curriculum to be taught to Tibetan monks and nuns in exile in India. Spearheaded by professor Arri Eisen and in close collaboration with monk Geshe Yungdrung Konchok, the aim is to integrate modern science (focusing on physics and life sciences, especially neuroscience) into their monastic curriculum.

(more…)